CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell lines HCT-116.

@article{Dittfeld2009CD133EI,
  title={CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell lines HCT-116.},
  author={Claudia Dittfeld and Antje Dietrich and Susann Peickert and Sandra L. Hering and Michael Baumann and Marian Grade and Thomas Ried and Leoni A. Kunz-Schughart},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2009},
  volume={92 3},
  pages={353-61}
}
BACKGROUND AND PURPOSE CD133 is controversially discussed as putative (surrogate) marker for cancer stem/tumor-initiating cell populations (CSC/TIC) in epithelial tumors including colorectal carcinomas (CRCs). We studied CD133 expression in established CRC cell lines and examined in vitro behavior, radioresponse and in vivo tumor formation of CD133(+/-) subpopulations of one cell line of interest. MATERIALS AND METHODS Ten CRC cell lines were analyzed for CD133 expression using flow cytometry… CONTINUE READING