CD133 expression defines a tumor initiating cell population in primary human ovarian cancer.

@article{Curley2009CD133ED,
  title={CD133 expression defines a tumor initiating cell population in primary human ovarian cancer.},
  author={Michael D. Curley and Vanessa A Therrien and Christine L Cummings and Petra A. Sergent and Carolyn R Koulouris and Anne M. Friel and Drucilla Jane Roberts and Michael V. Seiden and David T Scadden and Bo Ruben Rueda and Rosemary Foster},
  journal={Stem cells},
  year={2009},
  volume={27 12},
  pages={2875-83}
}
Evidence is accumulating that solid tumors contain a rare phenotypically distinct population of cells, termed cancer stem cells (CSC), which give rise to and maintain the bulk of the tumor. These CSC are thought to be resistant to current chemotherapeutic strategies due to their intrinsic stem-like properties and thus may provide the principal driving force behind recurrent tumor growth. Given the high frequency of recurrent metastasis associated with human ovarian cancer, we sought to… CONTINUE READING
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