CD133, Stem Cells, and Cancer Stem Cells: Myth or Reality?

  title={CD133, Stem Cells, and Cancer Stem Cells: Myth or Reality?},
  author={Xiazhen Yu and Yingjie Lin and Xie Yan and Qiang Tian and Linheng Li and Edward M. H. Lin},
  booktitle={Current colorectal cancer reports},
CD133, a member of the prominin family, is found in a variety of tissues with at least three variants. The function of CD133 is not well understood, but its expression is subject to changes in the microenvironment cues including bioenergetic stress. Knockout of CD133 does not affect renewal, but mammary gland branching. A point mutation of CD133 (R733C) leads to retinal disorder. CD133 is found in embryonic stem cells, normal tissue stem cells, stem cell niches, and circulating endothelial… CONTINUE READING
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