CD133+ renal progenitor cells contribute to tumor angiogenesis.

  title={CD133+ renal progenitor cells contribute to tumor angiogenesis.},
  author={Stefania Bruno and Benedetta Bussolati and Cristina Grange and Federica Collino and Manuela Efrem Graziano and Ugo Ferrando and Giovanni Camussi},
  journal={The American journal of pathology},
  volume={169 6},
In the present study, we tested the hypothesis that resident progenitor cells may contribute to tumor vascularization and growth. CD133+ cells were isolated from 30 human renal carcinomas and characterized as renal resident progenitor cells on the basis of the expression of renal embryonic and mesenchymal stem cell markers. CD133+ progenitors differentiated into endothelial and epithelial cells as the normal CD133+ counterpart present in renal tissue. In the presence of tumor-derived growth… CONTINUE READING
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