CD133+ adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF)

@article{Carter2009CD133AH,
  title={CD133+ adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF)},
  author={Debra A Carter and Andrew D Dick and Eric J Mayer},
  journal={BMC Ophthalmology},
  year={2009},
  volume={9},
  pages={1 - 1}
}
BACKGROUND CD133 is a cell surface marker of haematopoietic stem and progenitor cells. Leukaemia inhibitory factor (LIF), sustains proliferation and not differentiation of embryonic stem cells. We used CD133 to purify adult human retinal cells and aimed to determine what effect LIF had on these cultures and whether they still had the ability to generate neurospheres. METHODS Retinal cell suspensions were derived from adult human post-mortem tissue with ethical approval. With magnetic… CONTINUE READING