CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells.

@article{MinaOsorio2006CD13IC,
  title={CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells.},
  author={Paola Mina-Osorio and Linda H. Shapiro and Enrique Ortega},
  journal={Journal of leukocyte biology},
  year={2006},
  volume={79 4},
  pages={719-30}
}
Homotypic aggregation (HA) of cells plays key roles in physiological and pathological processes, such as embryogenesis, immune responses, angiogenesis, tumor cell invasion, and metastasis. Aminopeptidase N (CD13) has been implicated in most of these phenomena, although its participation has been attributed to its enzymatic activity, while its role as an adhesion molecule has been almost unexplored. Here, we show that certain anti-CD13 monoclonal antibodies induce HA of monocytic U-937 cells… CONTINUE READING

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