CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia.

@article{Foster2015CD11cCD18SV,
  title={CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia.},
  author={Greg A. Foster and Lu Xu and Alagu A. Chidambaram and Stephanie R Soderberg and Ehrin J Armstrong and Huaizhu Wu and Scott I Simon},
  journal={Journal of immunology},
  year={2015},
  volume={195 11},
  pages={5380-92}
}
Recruitment of foamy monocytes to inflamed endothelium expressing VCAM-1 contributes to the development of plaque during atherogenesis. Foamy CD11c(+) monocytes arise in the circulation during the onset of hypercholesterolemia and recruit to nascent plaque, but the mechanism of CD11c/CD18 and very late Ag-4 (VLA-4) activation and cooperation in shear-resistant cell arrest on VCAM-1 are ill defined. Within 1 wk of the onset of a Western high-fat diet (WD) in apolipoprotein E-deficient mice, an… CONTINUE READING
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