CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis.

@article{Dunne2009CD11cCD8alphaDC,
  title={CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis.},
  author={P{\'a}draic J. Dunne and Barry Moran and Robert C. Cummins and Kingston H G Mills},
  journal={Journal of immunology},
  year={2009},
  volume={183 1},
  pages={400-10}
}
CD11c(+)CD8alpha(+) and CD103(+) dendritic cells (DC) have been shown to promote regulatory T cell responses and mediate tolerance in the gastrointestinal tract. These cells have also been identified in the lung, but their role in immunity to respiratory tract infection is not clear. In this study, we have used a murine model of infection with Bordetella pertussis to examine the function of DC subtypes in protective immunity in the lungs. We found a dramatic increase in the numbers of CD11c… CONTINUE READING