CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis.

@article{Packard2008CD11cDC,
  title={CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis.},
  author={Ren{\'e} R S Packard and Elena Maganto-Garc{\'i}a and Israel Gotsman and Ira Tabas and P. Scott Libby and Andrew H. Lichtman},
  journal={Circulation research},
  year={2008},
  volume={103 9},
  pages={965-73}
}
Recent reports suggest dyslipidemia impairs dendritic cell (DC) function and adaptive immunity. This study aimed to characterize the effect of hypercholesterolemia on antigen-presenting cell function of DCs and DC-dependent CD4(+) T-cell responses. DCs incubated in vitro with acetylated low-density lipoprotein cholesterol with or without an acyl-coenzyme A:cholesterol acyl-transferase inhibitor maintained their ability to prime CD4(+) T cells. Analysis of T-cell proliferation and interferon… CONTINUE READING

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