CD11b expression distinguishes sequential stages of peritoneal B-1 development.

  title={CD11b expression distinguishes sequential stages of peritoneal B-1 development.},
  author={Eliver Eid Bou Ghosn and Yang Yang and James W. Tung and Leonard A. Herzenberg and Leonore Herzenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 13},
Peritoneal cavity (PerC) B-1 cells have long been known to express CD11b, which is coexpressed with CD18 to form the Mac-1/CR3 complement receptor and adhesion molecule. However, although all PerC B-1 cells are commonly believed to express CD11b, we show here that nearly half of the cells in each of the PerC B-1 subsets (B-1a and B-1b) do not express this surface receptor. The CD11b(+) cells in each B-1 subset are larger and more granular and express higher levels of surface IgM than the CD11b… CONTINUE READING

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