CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.

  title={CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.},
  author={Nader Ghasemlou and Isaac M Chiu and Jean-Pierre Julien and Clifford J Woolf},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 49},
Pain hypersensitivity at the site of inflammation as a result of chronic immune diseases, pathogenic infection, and tissue injury is a common medical condition. However, the specific contributions of the innate and adaptive immune system to the generation of pain during inflammation have not been systematically elucidated. We therefore set out to characterize the cellular and molecular immune response in two widely used preclinical models of inflammatory pain: (i) intraplantar injection of… CONTINUE READING
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