CD117 expression in breast phyllodes tumors correlates with adverse pathologic parameters and reduced survival

@article{Tan2015CD117EI,
  title={CD117 expression in breast phyllodes tumors correlates with adverse pathologic parameters and reduced survival},
  author={Wai Jin Tan and Aye Aye Thike and Sie Yong Jane Tan and Gary M Tse and Min-Han Tan and Boon-Huat Bay and Puay Hoon Tan},
  journal={Modern Pathology},
  year={2015},
  volume={28},
  pages={352-358}
}
CD117 (c-kit) is a type III receptor tyrosine kinase encoded by the KIT gene. Deregulation of expression and mutations in the gene are implicated in various tumors. Reports of CD117 expression in phyllodes tumors have been controversial. We aim to investigate the protein expression of CD117 and mutations in the KIT gene in phyllodes tumors, and correlate the findings with pathological parameters and clinical outcome. A total of 272 cases were included in this study. CD117 expression was… CONTINUE READING
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