CD105 inhibits transforming growth factor-beta-Smad3 signalling.

@article{Guo2004CD105IT,
  title={CD105 inhibits transforming growth factor-beta-Smad3 signalling.},
  author={Baoqiang Guo and Mark Slevin and Chenggang Li and Sudeep Parameshwar and Donghui Liu and P. R. Srikanta Kumar and Carmelo Bernabeu and Shant Kumar},
  journal={Anticancer research},
  year={2004},
  volume={24 3a},
  pages={1337-45}
}
CD105 (endoglin) is an important component of the transforming growth factor-beta (TGF-beta) receptor complex and is highly expressed in endothelial cells in tissues undergoing angiogenesis such as healing wounds, infarcts and in a wide range of tumours. In an attempt to understand the molecular mechanism by which CD105 exerts its effects on angiogenesis by modulating TGF-beta1 signalling, in this preliminary communication, CD105 transfected rat myoblasts were utilized as an in vitro model… CONTINUE READING

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