CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

@article{FloresLangarica2018CD103CD11bMC,
  title={CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin},
  author={Adriana Flores-Langarica and Katarzyna M Luda and Emma K. Persson and Charlotte N. L. Cook and Saeeda Bobat and John Marshall and Madelene W. Dahlgren and Karin H{\"a}gerbrand and Kai Michael Toellner and Margaret D Goodall and David R Withers and Ian R. Henderson and B Johansson Lindbom and Adam F Cunningham and William W. Agace},
  journal={Mucosal Immunology},
  year={2018},
  volume={11},
  pages={681-692}
}
Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103+CD11b+ (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103+CD11b− (SP) are not… CONTINUE READING