CD103(+) Dendritic Cells Control Th17 Cell Function in the Lung.

  title={CD103(+) Dendritic Cells Control Th17 Cell Function in the Lung.},
  author={Teresa Zelante and Alicia Yoke Wei Wong and Tang Jing Ping and Jinmiao Chen and Hermi Rizal Bin Sumatoh and Elena Vigan{\`o} and Yu Hong Bing and Bernett Teck Kwong Lee and Francesca Zolezzi and Jan Fric and Vincenzo W Cerundolo and Alessandra Mortellaro and Michael Poidinger and Paolo Puccetti and Paola Ricciardi-Castagnoli},
  journal={Cell reports},
  volume={12 11},
Th17 cells express diverse functional programs while retaining their Th17 identity, in some cases exhibiting a stem-cell-like phenotype. Whereas the importance of Th17 cell regulation in autoimmune and infectious diseases is firmly established, the signaling pathways controlling their plasticity are undefined. Using a mouse model of invasive pulmonary aspergillosis, we found that lung CD103(+) dendritic cells (DCs) would produce IL-2, dependent on NFAT signaling, leading to an optimally… CONTINUE READING
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