CD1-restricted T cell recognition of microbial lipoglycan antigens.

@article{Sieling1995CD1restrictedTC,
  title={CD1-restricted T cell recognition of microbial lipoglycan antigens.},
  author={Peter Allan Sieling and Debdutta Chatterjee and Steven A. Porcelli and Theodore I. Prigozy and R J Mazzaccaro and Teresa Soriano and Barry R. Bloom and Michael B Brenner and Mitchell Kronenberg and Patrick Joseph Brennan},
  journal={Science},
  year={1995},
  volume={269 5221},
  pages={
          227-30
        }
}
It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation… CONTINUE READING
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