CD1 antigen presentation: how it works

  title={CD1 antigen presentation: how it works},
  author={Duarte C Barral and Michael B Brenner},
  journal={Nature Reviews Immunology},
The classic concept of self–non-self discrimination by the immune system focused on the recognition of fragments from proteins presented by classical MHC molecules. However, the discovery of MHC-class-I-like CD1 antigen-presentation molecules now explains how the immune system also recognizes the abundant and diverse universe of lipid-containing antigens. The CD1 molecules bind and present amphipathic lipid antigens for recognition by T-cell receptors. Here, we outline the recent advances in… CONTINUE READING