CD1: A Singed Cat of the Three Antigen Presentation Systems

@inproceedings{Kaczmarek2017CD1AS,
  title={CD1: A Singed Cat of the Three Antigen Presentation Systems},
  author={Radoslaw Kaczmarek and Mariola Paściak and Katarzyna Szymczak-Kulus and Marcin Czerwiński},
  booktitle={Archivum Immunologiae et Therapiae Experimentalis},
  year={2017}
}
Contrary to general view that the MHC Class I and II are the kapellmeisters of recognition and response to antigens, there is another big player in that part of immunity, represented by CD1 glycoproteins. In contrast to MHC Class I or II, which present peptides, CD1 molecules present lipids. Humans express five CD1 proteins (CD1a-e), four of which (CD1a-d) are trafficked to the cell surface, where they may display lipid antigens to T-cell receptors. This interaction may lead to both non-cognate… CONTINUE READING
BETA
35
Twitter Mentions

References

Publications referenced by this paper.
SHOWING 1-10 OF 151 REFERENCES

NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

How the immune system detects lipid antigens.

  • Progress in lipid research
  • 2010
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

The easy virtue of CD1c.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

A subset of liver NK T cells is activated during Leishmania donovani infection by CD 1 d - bound lipophosphoglycan

BL Artiaga, G Yang, TJ Hackmann
  • J Exp Med
  • 2016

Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2016

Similar Papers

Loading similar papers…