CD Spectral Studies of Pb 2 + Interference with 5-Fluorouracil Induced DNA Structural Changes

Abstract

Lead (Pb) a common pollutant and known toxicant, and other various anti cancer drugs such as 5-fluorouracil bind to DNA competitively. Their efficacy as anti cancer drugs was brought by their mechanism of involvement with DNA and their interactive geometries. In this perspective we have designed CD spectral studies to investigate the interference of Pb with… (More)

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