CD Nomenclature 2015: Human Leukocyte Differentiation Antigen Workshops as a Driving Force in Immunology

  title={CD Nomenclature 2015: Human Leukocyte Differentiation Antigen Workshops as a Driving Force in Immunology},
  author={Pablo Engel and Laurence Boumsell and Robert Balderas and Armand Bensussan and Valter Gattei and Vaclav Hořej{\vs}{\'i} and Bo-Quan Jin and Fabio Malavasi and Frank Mortari and Reinhard Schwartz-Albiez and Hannes Stockinger and Menno C. van Zelm and Heddy Zola and Georgina J. Clark},
  journal={The Journal of Immunology},
  pages={4555 - 4563}
CD (cluster of differentiation) Ags are cell surface molecules expressed on leukocytes and other cells relevant for the immune system. CD nomenclature has been universally adopted by the scientific community and is officially approved by the International Union of Immunological Societies and sanctioned by the World Health Organization. It provides a unified designation system for mAbs, as well as for the cell surface molecules that they recognize. This nomenclature was established by the Human… 
Nomenclature of CD molecules from the Tenth Human Leucocyte Differentiation Antigen Workshop
The First International Human Leucocyte Differentiation Antigen (HLDA) Workshop was organised in the early 1980s, and aimed to identify groups of mAbs reacting with a common human cell-surface antigen and to agree a nomenclature that would facilitate better communication amongst the scientific community.
CD Maps—Dynamic Profiling of CD1–CD100 Surface Expression on Human Leukocyte and Lymphocyte Subsets
The results of the first phase of the CD Maps study are presented, mapping the expression of CD1–CD100 on 47 immune cell subsets from blood, thymus, and tonsil using an eight-color standardized EuroFlow approach and quantification of expression.
Standardization of Workflow and Flow Cytometry Panels for Quantitative Expression Profiling of Surface Antigens on Blood Leukocyte Subsets: An HCDM CDMaps Initiative
A procedure for quantitative expression profiling of surface antigens on blood leukocyte subsets is optimized and shows high reproducibility across centers, as well as the capacity to benchmark unique clones directed toward the same CD3 antigen.
Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein‐1 (CD71) as a Negative Selection Marker for Human Neuronal Cells
It is reported that in vitro human stem cell‐derived neurons lack CD71 surface expression and that the observed differential expression can be used to identify and enrich CD71− neuronal derivatives from heterogeneous cultures.
Update on Fc receptor-like (FCRL) family: new immunoregulatory players in health and diseases
Improved understanding of FCRL expression may grant B-cells and finally its signaling pathways, alone or in cooperation with other signaling molecules, as interesting new targets for diagnostic, monitoring and immunotherapeutic modalities; although further investigations remain to be defined.
A Proposal for Nomenclature in Myeloid C-Type Lectin Receptors
A standard nomenclature consisting of both gene names and consensus alias should be included at least in scientific abstracts, which would help to identify relevant literature, saving time and effort and fostering the research in this field in a more systematic manner.
CD34 cells in somatic, regenerative and cancer stem cells: Developmental biology, cell therapy, and omics big data perspective
The present understanding of the structure and putative functions of the CD34 molecule is reviewed based upon the literature survey and number of large‐scale proteomics and transcriptomics studies that have been performed using CD34+ cells are discussed.
CD11d is a novel antigen on chicken leukocytes.
The cell surface phenotype of human dendritic cells.


CD molecules 2005: human cell differentiation molecules.
The immune system works through leukocytes interacting with each other, with other cells, with tissue matrices, with infectious agents, and with other antigens. These interactions are mediated by
Medical Applications of Leukocyte Surface Molecules—the CD molecules
  • H. Zola
  • Biology, Medicine
    Molecular medicine
  • 2006
This short review provides a background to the CD molecules and antibodies against them, and summarizes research, diagnostic, and therapeutic applications of antibodies against these molecules.
How immunology is reshaping clinical disciplines: the example of haematology
Towards a comprehensive human cell-surface immunome database.
CD proteome and beyond - technologies for targeting the immune cell surfaceome.
Recent progress in the field towards the identification and quantification of the surfaceome as an important subproteome forming the information gateway of the cell is highlighted.
EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols
The 6 years of extensive collaborative experiments and the analysis of hundreds of cell samples of patients and healthy controls have provided for the first time laboratory protocols and software tools for fully standardized 8-color flow cytometric immunophenotyping of normal and malignant leukocytes in bone marrow and blood; this has yielded highly comparable data sets, which can be integrated in a single database.
GlycoCD: a repository for carbohydrate-related CD antigens
The main objective of this database platform is to provide information about interactions of carbohydrate moieties with proteins that are important for identification of specific cell surface molecule with a focus on the integration of data from carbohydrate microarray databases.
César Milstein, the father of modern immunology
In memoriam: César Milstein, who with the late Georges Köhler invented monoclonal antibodies, died on 24 March 2002. Their invention sprang from basic research on antibody diversity and specificity,
Some of the field’s leaders in atmospheric chemistry, in both the gas and the aerosol phases, provide insights in this volume of Topics in Current Chemistry.