CD 4+ T cells in the pathobiology of neurodegenerative disorders

  title={CD 4+ T cells in the pathobiology of neurodegenerative disorders},
  author={Xiuyan Huang and Ashley D. Reynolds and R. Lee Mosley and Howard E. Gendelman},
  journal={Journal of Neuroimmunology},
CD4+ T cells orchestrate innate and adaptive immunity. In the central nervous system they modulate immune responses including cell trafficking and glial neuroregulatory functions through an array of soluble molecules cell-cell interactions affecting tissue homeostasis. During disease their roles evolve to an auto-aggressive or, alternatively, protective phenotype. How such a balance is struck in the setting of neurodegenerative disorders may reflect a dichotomy between regulatory T cell, anti… CONTINUE READING


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