CD 18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI 3 Ks

@inproceedings{Anderson2008CD1A,
  title={CD 18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI 3 Ks},
  author={Karen E Anderson and Keith B. Boyle and Keith V. Davidson and Tamara A.-M. Chessa and Suhasini M. Kulkarni and Gavin E Jarvis and Anca Sindrilaru and Karin Scharffetter-Kochanek and Oliver Lars Rausch and Len R. Stephens and Phillip T. Hawkins},
  year={2008}
}
Phagocytosis and activation of the NADPH oxidase are important mechanisms by which neutrophils and macrophages engulf and kill microbial pathogens. We investigated the role of PI3K signaling pathways in the regulation of the oxidase during phagocytosis of Staphylococcus aureus and Escherichia coli by mouse and human neutrophils, a mouse macrophage-like cell line and a human myeloid-like cell line. Phagocytosis of these bacteria was promoted by serum, independent of serum-derived antibodies, and… CONTINUE READING

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