CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat

BACKGROUND Rutin is a polyphenolic natural flavonoid which possesses antioxidant and anticancer activity. In the present study the hepatoprotective effect of rutin was evaluated against carbon tetrachloride (CCl₄)-induced liver injuries in rats. METHODS AND MATERIALS 24 Sprague-Dawley male rats were equally divided into 4 groups for the assessment of… CONTINUE READING