CCSVI and MS: no meaning, no fact

  title={CCSVI and MS: no meaning, no fact},
  author={C. Baracchini and M. Atzori and P. Gallo},
  journal={Neurological Sciences},
  • C. Baracchini, M. Atzori, P. Gallo
  • Published 2012
  • Medicine
  • Neurological Sciences
  • A condition called “chronic cerebrospinal venous insufficiency” (CCSVI) has been postulated to play a role in the pathogenesis of multiple sclerosis (MS). This hypothesis implies that a complex pattern of extracranial venous stenosis determines a venous reflux into the brain of MS patients, followed by increased intravenous pressure, blood–brain barrier breakdown and iron deposition into the brain parenchyma, thus triggering a local inflammatory response. In this review, we critically analyze… CONTINUE READING
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