CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.

@article{Papadakis2001CCR9positiveLA,
  title={CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.},
  author={Konstantinos A. Papadakis and John L. Prehn and Sofia T. Moreno and L Cheng and Elias Kouroumalis and Richard Deem and T Breaverman and Paul D. Ponath and David P. Andrew and Peter H. R. Green and Martin R. Hodge and Scott Binder and Stephan R. Targan},
  journal={Gastroenterology},
  year={2001},
  volume={121 2},
  pages={
          246-54
        }
}
BACKGROUND & AIMS Thymus-expressed chemokine (TECK) or CCL25) is selectively expressed in the small bowel (SB), where lamina propria lymphocytes (LPL) and intraepithelial leukocyte expressing the cognate chemokine receptor CCR9 predominate. We characterize the role of TECK and CCR9-expresing lymphocytes in small intestinal Crohn's disease. METHODS CCR9 expression on lymphocytes from lamina propria, mesenteric lymph node, and peripheral blood was analyzed by flow cytometry and by Northern… CONTINUE READING

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