CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

@article{Buonamici2009CCR7SA,
  title={CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia},
  author={Silvia Buonamici and Thomas Trimarchi and Maria Grazia Ruocco and Linsey Reavie and S{\'e}verine Cathelin and Brenton G. Mar and Apostolos Klinakis and Yevgeniy Lukyanov and Jen-Chieh Tseng and Filiz Şen and Eric A Gehrie and Mengling Li and Elizabeth Wormwood Newcomb and Jiri Zavadil and Daniel Meruelo and Martin Lipp and Malgwi Samaila Ibrahim and A. Efstratiadis and David Zagzag and Jonathan S. Bromberg and Michael L. Dustin and Iannis Aifantis},
  journal={Nature},
  year={2009},
  volume={459},
  pages={1000-1004}
}
T-cell acute lymphoblastic leukaemia (T-ALL) is a blood malignancy afflicting mainly children and adolescents. T-ALL patients present at diagnosis with increased white cell counts and hepatosplenomegaly, and are at an increased risk of central nervous system (CNS) relapse. For that reason, T-ALL patients usually receive cranial irradiation in addition to intensified intrathecal chemotherapy. The marked increase in survival is thought to be worth the considerable side-effects associated with… CONTINUE READING
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much more than chemotaxis and inflammation

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