CCR7 directs the migration of thymocytes into the thymic medulla.

Abstract

Developing thymocytes migrate from the cortex to the medulla of the thymus as a consequence of positive selection. This migration is likely to be essential for tolerance because it allows the developing cells to move into an environment that is optimal for negative selection. Guidance mechanisms that draw positively selected thymocytes into the medulla have… (More)

Topics

  • Presentations referencing similar topics