CCR7 and its ligands: balancing immunity and tolerance

  title={CCR7 and its ligands: balancing immunity and tolerance},
  author={Reinhold Foerster and Ana Clara Marques Davalos-Misslitz and Antal Rot},
  journal={Nature Reviews Immunology},
A key feature of the immune system is its ability to induce protective immunity against pathogens while maintaining tolerance towards self and innocuous environmental antigens. Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance. This receptor is involved in organizing thymic architecture and function, lymph-node homing of naive and regulatory T cells via high endothelial venules, as… CONTINUE READING
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