CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

@article{Foerster1999CCR7CT,
  title={CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs},
  author={Reinhold Foerster and Andreas Schubel and Dagmar Breitfeld and Elisabeth Kremmer and Ingrid Renner-Mueller and Eckhard Wolf and Martin Lipp},
  journal={Cell},
  year={1999},
  volume={99},
  pages={23-33}
}
The proper function of immune surveillance requires well-coordinated mechanisms in order to guide the patrolling immune cells through peripheral tissues and into secondary lymphoid organs. Analyzing gene-targeted mice, we identified the chemokine receptor CCR7 as an important organizer of the primary immune response. CCR7-deficient mice show severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions. Due to the impaired… CONTINUE READING
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