CCR7+ Central and CCR7− Effector Memory CD4+ T Cells in Human Cutaneous Leishmaniasis

@article{Valian2012CCR7CA,
  title={CCR7+ Central and CCR7− Effector Memory CD4+ T Cells in Human Cutaneous Leishmaniasis},
  author={Hossein Keshavarz Valian and Mahmoud Nateghi Rostami and Minoo Tasbihi and Akram Miramin Mohammadi and Seyed Ebrahim Eskandari and Abdolfattah Sarrafnejad and Ali Khamesipour},
  journal={Journal of Clinical Immunology},
  year={2012},
  volume={33},
  pages={220-234}
}
The profile of central (=TCM) and effector (=TEM) memory CD4+ T cell subsets and the possible role as surrogate markers of protection is studied in the volunteers with history of cutaneous leishmaniasis (HCL). Profile of T cell subsets based on CCR7/CD45RA expressions and phenotypic changes after soluble Leishmania antigen (SLA) stimulation were analyzed. Then, sorted CD4+CD45RO−CD45RA+ naïve T, CD4+CD45RO+CD45RA−CCR7− TEM, CD4+CD45RO+CD45RA−CCR7+ TCM subsets were cultured with SLA for… CONTINUE READING
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