CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells

  title={CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells},
  author={J{\'u}lio C. S. Aliberti and Caetano Reis e Sousa and Marco Schito and Sara Hieny and Timothy Wells and Gary B Huffnagle and Alan Sher},
  journal={Nature Immunology},
The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C–C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8α+ subset of DC and that this pathway is important in establishing interferon γ-dependent resistance to the protozoan parasite Toxoplasma gondii. These findings support the concept that… CONTINUE READING

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