CCR5 is characteristic of Th1 lymphocytes

  title={CCR5 is characteristic of Th1 lymphocytes},
  author={Pius Loetscher and Mariagrazia Uguccioni and Lorenza Bordoli and Marco Baggiolini and Bernhard Moser and Carlo Chizzolini and Jean-Michel Dayer},
CD4+ lymphocytes can be assigned to two subsets. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the chemokine receptor CCR3 (refs 2 b3). We have studied the occurrence of two additional chemokine receptors, CCR5 and CXCR3, in human, antigen-specific CD4… CONTINUE READING
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