CCR5 inhibitors: emergence, success, and challenges.

  title={CCR5 inhibitors: emergence, success, and challenges.},
  author={Kenji Maeda and Debananda Das and Hirotomo Nakata and Hiroaki Mitsuya},
  journal={Expert opinion on emerging drugs},
  volume={17 2},
INTRODUCTION The discovery of CC-chemokine receptor 5 (CCR5) as a human immunodeficiency virus type 1 (HIV-1) coreceptor opened a new avenue to exploit CCR5 as a potential target for the intervention of HIV-1's cellular entry. AREAS COVERED Various small-molecule CCR5 inhibitors were identified in the last decade; however, maraviroc (MVC) is the only CCR5 inhibitor currently used in the clinic. Concerns and challenges that exist for wider clinical use of CCR5 inhibitors are discussed… CONTINUE READING
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-6 of 6 citations