CCR5 inhibitors: emergence, success, and challenges.

@article{Maeda2012CCR5IE,
  title={CCR5 inhibitors: emergence, success, and challenges.},
  author={Kenji Maeda and Debananda Das and Hirotomo Nakata and Hiroaki Mitsuya},
  journal={Expert opinion on emerging drugs},
  year={2012},
  volume={17 2},
  pages={
          135-45
        }
}
INTRODUCTION The discovery of CC-chemokine receptor 5 (CCR5) as a human immunodeficiency virus type 1 (HIV-1) coreceptor opened a new avenue to exploit CCR5 as a potential target for the intervention of HIV-1's cellular entry. AREAS COVERED Various small-molecule CCR5 inhibitors were identified in the last decade; however, maraviroc (MVC) is the only CCR5 inhibitor currently used in the clinic. Concerns and challenges that exist for wider clinical use of CCR5 inhibitors are discussed… CONTINUE READING
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