CCR5 expression on monocytes and T cells: modulation by transmigration across the blood-brain barrier in vitro.

@article{Ubogu2006CCR5EO,
  title={CCR5 expression on monocytes and T cells: modulation by transmigration across the blood-brain barrier in vitro.},
  author={Eroboghene E Ubogu and Melissa K. Callahan and Barbara H. Tucky and Richard M Ransohoff},
  journal={Cellular immunology},
  year={2006},
  volume={243 1},
  pages={19-29}
}
Observational studies in multiple sclerosis (MS) demonstrated altered expression of chemokine receptors (CkRs) on comparable populations of mononuclear cells (e.g. CD4(+)/CD45RO(+) T-cells) in brain sections compared with blood. These findings raised questions about the regulation of CkRs on trafficking cells. Regulatory processes for CkRs are complex: examples include down-regulation following ligand engagement during migration and either up- or down-regulation following activation… CONTINUE READING

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