CCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5 HIV-1.

@article{Heredia2007CCR5DL,
  title={CCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5 HIV-1.},
  author={Alonso Heredia and Bruce Gilliam and Anthony L. Devico and Nhut Le and Douty Bamba and Robin Flinko and George Henry Lewis and RobertC. Gallo and Robert R Redfield},
  journal={AIDS},
  year={2007},
  volume={21 10},
  pages={
          1317-22
        }
}
OBJECTIVE AND DESIGN Studies in cell lines have demonstrated that CCR5 coreceptor levels influence the replication efficiency and Enfuvirtide (T-20) susceptibility of R5 HIV-1 strains. At present, however, the role that CCR5 levels on primary CD4 T cells--which are markedly lower than in cell lines and vary only approximately fivefold among most donors--may play in virus replication levels or susceptibility to T-20 is not known. In the present study we evaluated the impact of differences in… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

Similar Papers

Loading similar papers…