CCR5 deficiency exacerbates T-cell-mediated hepatitis in mice.

  title={CCR5 deficiency exacerbates T-cell-mediated hepatitis in mice.},
  author={Christophe Moreno and Thierry Gustot and Charles Nicaise and Eric Quertinmont and Nathalie Nagy and Marc Parmentier and Olivier le Moine and Jacques Devi{\'e}re and Hubert Louis},
  volume={42 4},
Experimental T-cell-mediated hepatitis induced by concanavalin A (Con A) involves the production of different cytokines and chemokines and is characterized by leukocyte infiltration. Because the chemokine receptor CCR5 and its ligands (CCL3, CCL4, and CCL5) regulate leukocyte chemotaxis and activation, we investigated the role of CCR5 during Con A-induced liver injury. Serum levels of CCR5 ligands and their hepatic transcript levels were significantly increased after Con A injection, whereas… CONTINUE READING


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