CCR5 blockade in combination with cyclosporine increased cardiac graft survival and generated alternatively activated macrophages in primates.

@article{Li2011CCR5BI,
  title={CCR5 blockade in combination with cyclosporine increased cardiac graft survival and generated alternatively activated macrophages in primates.},
  author={Jun Li and Gang Chen and Ping Ye and Sihua Wang and Kailun Zhang and Wenhao Chen and Stanislaw M. Stepkowski and Junhua Li and Shan Zhong and Jiahong Xia},
  journal={Journal of immunology},
  year={2011},
  volume={186 6},
  pages={3753-61}
}
Maraviroc (MVC), a specific antagonist of CCR5 expressed on macrophages and activated T cells, may modulate inflammation and may be useful in patients with HIV infection. In this study we used nonhuman primates to examine the effect and mechanism of MVC alone or in combination with cyclosporine (CsA) to prolong cardiac allograft survivals. In an established rhesus monkey cardiac allograft model, recipients treated with MVC plus CsA showed significantly prolonged survival of heart allografts… CONTINUE READING