CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo.

Abstract

CCR5-utilizing (R5) and CXCR4-utilizing (X4) strains of human immunodeficiency virus type 1 (HIV-1) have been studied intensively in vitro, but the pathologic correlates of such differential tropism in vivo remain incompletely defined. In this study, X4 and R5 strains of HIV-1 were compared for tropism and pathogenesis in SCID-hu Thy/Liv mice, an in vivo… (More)

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Cite this paper

@article{Berkowitz1998CCR5AC, title={CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo.}, author={R D Berkowitz and Stephen P. H. Alexander and Christopher Bare and Valerie D. Linquist-Stepps and Mark Bogan and Mary E. Moreno and Laura F. Gibson and Eric D. Wieder and Jon C. Kosek and Cheryl A Stoddart and Joseph M McCune}, journal={Journal of virology}, year={1998}, volume={72 12}, pages={10108-17} }