CCR5 Antagonists: Host-Targeted Antivirals for the Treatment of HIV Infection

@article{Westby2005CCR5AH,
  title={CCR5 Antagonists: Host-Targeted Antivirals for the Treatment of HIV Infection},
  author={Mike Westby and E van der Ryst},
  journal={Antiviral Chemistry and Chemotherapy},
  year={2005},
  volume={16},
  pages={339 - 354}
}
The human chemokine receptors, CCR5 and CXCR4, are potential host targets for exogenous, small-molecule antagonists for the inhibition of HIV-1 infection. HIV-1 strains can be categorised by co-receptor tropism — their ability to utilise CCR5 (CCR5-tropic), CXCR4 (CXCR4-tropic) or both (dual-tropic) as a co-receptor for entry into susceptible cells. CCR5 may be the more suitable co-receptor target for small-molecule antagonists because a natural deletion in the CCR5 gene preventing its… 

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