CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis.

  title={CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis.},
  author={J. Q. Li and Sara McArdle and Amin M Gholami and Takayuki Kimura and Dennis Wolf and Teresa Gerhardt and Jacqueline F. Miller and Christian Weber and Klaus Ley},
  journal={Circulation research},
  volume={118 10},
RATIONALE CD4 T cells are involved in the pathogenesis of atherosclerosis, but atherosclerosis-specific CD4 T cells have not been described. Moreover, the chemokine(s) that regulates T-cell trafficking to the atherosclerotic lesions is also unknown. OBJECTIVE In Apoe(-/-) mice with mature atherosclerotic lesions (5 months of high fat diet), we find that most aortic T cells express CCR5 and interferon-γ with a unique combination of cell surface markers (CD4(+)CD25(-)CD44(hi)CD62L(lo)) and… CONTINUE READING
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