CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions.

  title={CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions.},
  author={Carolin Blattner and Viktor Fleming and Rebekka Weber and Bianca Himmelhan and Peter Altevogt and Christoffer Gebhardt and Torsten J. Schulze and Hila Razon and Elias Hawila and Gizi Wildbaum and Jochen Sven Utikal and Nathan Karin and Viktor Umansky},
  journal={Cancer research},
  volume={78 1},
Accumulation of myeloid-derived suppressor cells (MDSC) in melanoma microenvironment is supported by chemokine receptor/chemokine signaling. Although different chemokines were suggested to be involved in this process, the role of CCR5 and its ligands is not established. Using a Ret transgenic mouse melanoma model, we found an accumulation of CCR5+ MDSCs in melanoma lesions associated with both increased concentrations of CCR5 ligands and tumor progression. Tumor-infiltrating CCR5+ MDSCs… CONTINUE READING
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