CCR4 is a determinant of melanoma brain metastasis

  title={CCR4 is a determinant of melanoma brain metastasis},
  author={Anat Klein and Orit Sagi-Assif and Tsipi Meshel and Alona Telerman and Sivan Izraely and Shlomit Ben-Menachem and Jagadeesh Bayry and Diego M Marzese and Shuichi Ohe and Dave S B Hoon and Neta Erez and Isaac P Witz},
We previously identified the chemokine receptor CCR4 as part of the molecular signature of melanoma brain metastasis. The aim of this study was to determine the functional significance of CCR4 in melanoma brain metastasis. We show that CCR4 is more highly expressed by brain metastasizing melanoma cells than by local cutaneous cells from the same melanoma. Moreover, we found that the expression of CCR4 is significantly higher in paired clinical specimens of melanoma metastases than in samples of… CONTINUE READING

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