CCR4 and its ligands: from bench to bedside.

  title={CCR4 and its ligands: from bench to bedside.},
  author={Osamu Yoshie and Kouji Matsushima},
  journal={International immunology},
  volume={27 1},
Chemokines and chemokine receptors orchestrate cell migration and homing in the body. Humans have at least 44 chemokines that are further classified into four subfamilies based on the N-terminal conserved cysteine motifs: CXC, CC, C and CX3C. All the known chemokine receptors are seven transmembrane-type receptors. Humans have 18 chemotactic and 5 atypical non-chemotactic (recycling or scavenging) receptors. CC chemokine receptor 4 (CCR4) is the receptor for two CC chemokine ligands (CCLs… CONTINUE READING


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Anti - CCR 4 mAb selectively depletes effectortype FoxP 3 + CD 4 + regulatory T cells , evoking antitumor immune responses in humans

  • B. D. Sather, P. Treuting, N. Perdue
  • Proc . Natl Acad . Sci . USA
  • 2013

Compartmentalized chemokinedependent regulatory T - cell inhibition of allergic pulmonary inflammation

  • D. Sugiyama, H. Nishikawa, Y. Maeda
  • J . Allergy Clin . Immunol .
  • 2013

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