CCR4 and its ligands: from bench to bedside.

@article{Yoshie2015CCR4AI,
  title={CCR4 and its ligands: from bench to bedside.},
  author={Osamu Yoshie and Kouji Matsushima},
  journal={International immunology},
  year={2015},
  volume={27 1},
  pages={11-20}
}
Chemokines and chemokine receptors orchestrate cell migration and homing in the body. Humans have at least 44 chemokines that are further classified into four subfamilies based on the N-terminal conserved cysteine motifs: CXC, CC, C and CX3C. All the known chemokine receptors are seven transmembrane-type receptors. Humans have 18 chemotactic and 5 atypical non-chemotactic (recycling or scavenging) receptors. CC chemokine receptor 4 (CCR4) is the receptor for two CC chemokine ligands (CCLs… CONTINUE READING

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