CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11

  title={CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11},
  author={Georgina Xanthou and C{\'e}cile E Duchesnes and Timothy John Williams and James Edward Pease},
  journal={European Journal of Immunology},
The chemokine receptor CXCR3 is predominantly expressed on T lymphocytes, and its agonists CXCL9, CXCL10 and CXCL11 are IFN‐γ‐inducible chemokines that promote Th1 responses. In contrast, the CCR3 agonists CCL11, CCL24 and CCL26 are involved in the recruitment of cells such as eosinophils and basophils during Th2 responses. Here, we report that although CCL11, CCL24 and CCL26 are neither agonists nor antagonists of CXCR3, CCL11 binds with high affinity to CXCR3. This suggests that, in vivo… 

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