CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

  title={CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia},
  author={J. He and Y. Chen and M. Farzan and H. Choe and A. Ohagen and S. Gartner and J. Busciglio and X. Yang and W. Hofmann and W. Newman and C. Mackay and J. Sodroski and D. Gabuzda},
  • J. He, Y. Chen, +10 authors D. Gabuzda
  • Published 1997
  • Biology, Medicine
  • Nature
  • Several members of the chemokine receptor family are used together with CD4 for HIV-1 entry into target cells1–6. T cell line-tropic (T-tropic) HIV-1 viruses use the chemokine receptor CXCR4 as a co-receptor1, whereas macrophage-tropic (M-tropic) primary viruses use CCR5 (refs 2–6). Individuals with defective CCR5 alleles exhibit resistance to HIV-1 infection7,8, suggesting that CCR5 has an important role in vivo in HIV-1 replication. A subset of primary viruses can use CCR3 as well as CCR5 as… CONTINUE READING
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