CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.

@article{Willenborg2012CCR2RA,
  title={CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.},
  author={Sebastian Willenborg and Tina Lucas and Geert van Loo and Johanna A Knipper and Thomas Krieg and Ingo Haase and Bent Brachvogel and Matthias Hammerschmidt and Andras D Nagy and Napoleone M. A. Ferrara and Manolis Pasparakis and Sabine A Eming},
  journal={Blood},
  year={2012},
  volume={120 3},
  pages={613-25}
}
Monocytes/macrophages are critical in orchestrating the tissue-repair response. However, the mechanisms that govern macrophage regenerative activities during the sequential phases of repair are largely unknown. In the present study, we examined the dynamics and functions of diverse monocyte/macrophage phenotypes during the sequential stages of skin repair. By combining the analysis of a new CCR2-eGFP reporter mouse model with conditional mouse mutants defective in myeloid cell-restricted CCR2… CONTINUE READING
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