CCR2 promotes hepatic fibrosis in mice.

  title={CCR2 promotes hepatic fibrosis in mice.},
  author={Ekihiro Seki and Samuele de Minicis and Sayaka Inokuchi and Kojiro Taura and Katsumi Miyai and Nico Van Rooijen and Robert F. Schwabe and David Brenner},
  volume={50 1},
UNLABELLED Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells (HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of CCR2, the receptor for monocyte chemoattractant protein (MCP)-1, MCP-2, and MCP-3, in hepatic fibrosis. Hepatic CCR2, MCP-1, MCP-2, and MCP-3 messenger RNA expression was increased after bile duct ligation (BDL). Both Kupffer cells and HSCs, but not hepatocytes, expressed CCR2. BDL- and CCl(4)-induced… CONTINUE READING
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