CCR2 is required for CD8-induced graft-versus-host disease.

  title={CCR2 is required for CD8-induced graft-versus-host disease.},
  author={Theis H. Terwey and Theo Daniel Kim and Adam A. Kochman and Vanessa M. Hubbard and Sydney X. Lu and Johannes L. Zakrzewski and Teresa Ramirez-Montagut and Jeffrey M. Eng and Stephanie J. Muriglan and Glenn Heller and George Murphy and Chen Liu and Tulin Budak-Alpdogan and Onder S Alpdogan and Marcel R M van den Brink},
  volume={106 9},
Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). Migration of donor-derived T cells into GVHD target organs plays a critical role in the development of GVHD and chemokines and their receptors are important molecules involved in this process. Here, we demonstrate in murine bone marrow transplantation models that the expression of the inflammatory CC chemokine receptor 2 (CCR2) on donor-derived CD8+ T cells is relevant for the… CONTINUE READING
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