CCR2 deficiency prevents neuronal dysfunction and cognitive impairments induced by cranial irradiation.

@article{Belarbi2013CCR2DP,
  title={CCR2 deficiency prevents neuronal dysfunction and cognitive impairments induced by cranial irradiation.},
  author={Karim Belarbi and Timothy D. Jopson and Carla Arellano and John R. Fike and Susanna Rosi},
  journal={Cancer research},
  year={2013},
  volume={73 3},
  pages={
          1201-10
        }
}
Cranial irradiation can lead to long-lasting cognitive impairments in patients receiving radiotherapy for the treatment of malignant brain tumors. Recent studies have suggested inflammation as a major contributor to these deficits; we determined if the chemokine (C-C motif) receptor 2 (CCR2) was a mediator of cognitive impairments induced by irradiation. Two-month-old male Ccr2 knockout (-/-) and wild-type mice received 10 Gy cranial irradiation or sham-treatment. One month after irradiation… CONTINUE READING

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