CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis.

  title={CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis.},
  author={Rachel E Miller and Phuong B. Tran and Rosalina Das and Nayereh Ghoreishi-Haack and Dongjun Ren and Richard J. Miller and A M Malfait},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 50},
Osteoarthritis is one of the leading causes of chronic pain, but almost nothing is known about the mechanisms and molecules that mediate osteoarthritis-associated joint pain. Consequently, treatment options remain inadequate and joint replacement is often inevitable. Here, we use a surgical mouse model that captures the long-term progression of knee osteoarthritis to longitudinally assess pain-related behaviors and concomitant changes in the innervating dorsal root ganglia (DRG). We demonstrate… CONTINUE READING
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